Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells

Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by progerin, a mutant lamin A variant. HGPS patients display accelerated aging and die prematurely, typically from atherosclerosis complications. Recently, we demonstrated that progerin‐driven vascular smooth musc...

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Bibliographic Details
Main Authors: Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Format: Article
Language:English
Published: Springer Nature 2019-03-01
Series:EMBO Molecular Medicine
Subjects:
aging
endoplasmic reticulum stress
progeria
unfolded protein response
vascular smooth muscle cell
Online Access:https://doi.org/10.15252/emmm.201809736

Internet

https://doi.org/10.15252/emmm.201809736

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