Carvedilol Precipitation Inhibition by the Incorporation of Polymeric Precipitation Inhibitors Using a Stable Amorphous Solid Dispersion Approach: Formulation, Characterization, and <i>In Vitro In Vivo</i> Evaluation

Carvedilol Precipitation Inhibition by the Incorporation of Polymeric Precipitation Inhibitors Using a Stable Amorphous Solid Dispersion Approach: Formulation, Characterization, and <i>In Vitro In Vivo</i> Evaluation

An amorphous solid dispersion (ASD) of carvedilol (CVL) was prepared via the solvent evaporation method, using cellulose derivatives as polymeric precipitation inhibitors (PPIs). The prepared ASDs existed in the amorphous phase, as revealed by X-ray powder diffraction (XRPD) and scanning electron mi...

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Bibliographic Details
Main Authors: Akhila Akkihebbal Ravikumar, Parthasarathi K. Kulkarni, Riyaz Ali M. Osmani, Umme Hani, Mohammed Ghazwani, Adel Al Fatease, Ali H. Alamri, Devegowda V. Gowda
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Polymers
Subjects:
drug delivery
drug precipitation
amorphous solid dispersions
carvedilol
cellulose
crystallization
Online Access:https://www.mdpi.com/2073-4360/14/22/4977

Internet

https://www.mdpi.com/2073-4360/14/22/4977

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