Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo

Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo

Zinc (Zn2+) is considered as important mediator of immune cell function, thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn2+ homeostasis in platelets is limited. Zn2+ transporters, ZIPs and ZnTs, are widely expressed in eukaryotic cells. Using mice g...

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Bibliographic Details
Main Authors: Amro Elgheznawy, Patricia Öftering, Maximilian Englert, Kristina Mott, Friederike Kaiser, Charly Kusch, Uwe Gbureck, Michael R. Bösl, Harald Schulze, Bernhard Nieswandt, Timo Vögtle, Heike M. Hermanns
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
platelets
zinc
ZIP
thrombin
signaling
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197894/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197894/full

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