MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

Synucleinopathies, neurodegenerative disorders with alpha-synuclein (α-syn) accumulation, are the second leading cause of neurodegeneration in the elderly, however no effective disease-modifying alternatives exist for these diseases. Multiple system atrophy (MSA) is a fatal synucleinopathy character...

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Bibliographic Details
Main Authors: Elvira Valera, Brian Spencer, Jennifer Mott, Margarita Trejo, Anthony Adame, Michael Mante, Edward Rockenstein, Juan C. Troncoso, Thomas G. Beach, Eliezer Masliah, Paula Desplats
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microRNA
multiple system atrophy
autophagy
alpha-synuclein
miR-101
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00329/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00329/full

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