Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B.

Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B.

Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cryo-EM structures of full-length TcdB in complex wit...

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Bibliographic Details
Main Authors: Mengqiu Jiang, Joonyoung Shin, Rudo Simeon, Jeng-Yih Chang, Ran Meng, Yuhang Wang, Omkar Shinde, Pingwei Li, Zhilei Chen, Junjie Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001589

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https://doi.org/10.1371/journal.pbio.3001589

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