PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome

PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome

High grade serous ovarian cancer (HGSC) arises from the fimbriated end of the fallopian tube epithelium (FTE), and in some cases, the ovarian surface epithelium (OSE). PAX8 is a commonly used biomarker for HGSC and is expressed in ∼90% of HGSC. Although the OSE does not express PAX8, murine models o...

Full description

Bibliographic Details
Main Authors: Amrita Salvi, Laura R. Hardy, Kimberly N. Heath, Samantha Watry, Melissa R. Pergande, Stephanie M. Cologna, Joanna E. Burdette
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Tumor microenvironment
PAX8
Fibronectin
Tumor spheroids
Ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000914

Internet

http://www.sciencedirect.com/science/article/pii/S1476558622000914

Similar Items