Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study

Abstract Background In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during continuous renal replacement therapy compared to patie...

Full description

Bibliographic Details
Main Authors: Tjokosela Tikiso, Valentin Fuhrmann, Christina König, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G. Wicha, Jörn Grensemann
Format: Article
Language:English
Published: SpringerOpen 2023-09-01
Series:Annals of Intensive Care
Subjects:
Antibiotics
Target attainment
Intensive care
Volume of distribution
Monte-Carlo simulation
Population pharmacokinetics
Online Access:https://doi.org/10.1186/s13613-023-01184-z

Internet

https://doi.org/10.1186/s13613-023-01184-z

Similar Items