Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia

Uncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia

Rapid removal of glutamate from the sites of glutamate release is an essential step in excitatory synaptic transmission. However, despite many years of research, the molecular mechanisms underlying the intracellular regulation of glutamate transport at tripartite synapses have not been fully uncover...

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Bibliographic Details
Main Authors: Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Lättig-Tünnemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocyte activation
Huntington’s disease (HD)
EAAT2 interaction proteomics
synaptic glutamate clearance
corticostriatal pathology
hypokinesia
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.792652/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.792652/full

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