Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease

Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer’s disease

Abstract Background Cerebrospinal fluid (CSF) biomarkers of synaptic dysfunction, neuroinflammation, and glial response, complementing Alzheimer’s disease (AD) core biomarkers, have improved the pathophysiological characterization of the disease. Here, we tested the hypothesis that the co-expression...

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Bibliographic Details
Main Authors: Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J. Ashton, Thomas K. Karikari, Ann Brinkmalm-Westman, Juan Lantero-Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M. Arenaza-Urquijo, for the ALFA study
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
CSF biomarkers
Hierarchical clustering
β-amyloid
ATN
Sporadic Alzheimer’s disease
ALFA cohort
Online Access:https://doi.org/10.1186/s13195-024-01629-y

Internet

https://doi.org/10.1186/s13195-024-01629-y

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