25-hydroxyvitamin D3 generates immunomodulatory plasticity in human periodontal ligament-derived mesenchymal stromal cells that is inflammatory context-dependent

25-hydroxyvitamin D3 generates immunomodulatory plasticity in human periodontal ligament-derived mesenchymal stromal cells that is inflammatory context-dependent

IntroductionHuman periodontal ligament-derived mesenchymal stromal cells (hPDL-MSCs) exhibit a tight bi-directional interaction with CD4+ T lymphocytes. The hPDL-MSCs’ immunomodulatory abilities are drastically enhanced by pro-inflammatory cytokines via boosting the expression of various immunomedia...

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Bibliographic Details
Main Authors: Christian Behm, Alice Blufstein, Johannes Gahn, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
25-hydroxyvitamin D3
mesenchymal stromal cells
periodontal ligament
immunomodulation
tumor necrosis factor alpha
interleukin-1 beta
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1100041/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1100041/full

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