MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice

MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice

Abstract Background Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechanism of PND is unclear, and no effective therapies are currently available. It is believed that neuroinflammation plays an important role in tri...

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Bibliographic Details
Main Authors: Wenqiang Zuo, Jianshuai Zhao, Jinming Zhang, Zongping Fang, Jiao Deng, Ze Fan, Yaru Guo, Jing Han, Wugang Hou, Hailong Dong, Feifei Xu, Lize Xiong
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Perioperative neurocognitive disorder
Aged mice
MD2
α5GABAAR
Online Access:https://doi.org/10.1186/s12974-021-02246-4

Internet

https://doi.org/10.1186/s12974-021-02246-4

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