Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer

Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer

Abnormal expression of microRNA miR-214-3p (miR-214) is associated with multiple cancers. In this study, we assessed the effects of CRISPR/Cas9 mediated miR-214 depletion in prostate cancer (PCa) cells and the underlying mechanisms. Knockdown of miR-214 promoted PCa cell proliferation, invasion, mig...

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Bibliographic Details
Main Authors: Patrice Cagle, Nikia Smith, Timothy O. Adekoya, Yahui Li, Susy Kim, Leslimar Rios-Colon, Gagan Deep, Suryakant Niture, Christopher Albanese, Simeng Suy, Sean P. Collins, Deepak Kumar
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
CRISPR/Cas9
microRNA
prostate cancer
EMT
RNA sequencing
Online Access:https://www.mdpi.com/2072-6694/13/23/5875

Internet

https://www.mdpi.com/2072-6694/13/23/5875

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