Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines in vitro. Most of the compounds showed satisfacto...

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Bibliographic Details
Main Authors: Xiaobo Liu, Yuzhen Li, Qian Zhang, Qingshan Pan, Pengwu Zheng, Xinyang Dai, Zhaoshi Bai, Wufu Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Chemistry
Subjects:
c-Met inhibitor
antiproliferative activity
antitumor
targeted drug
pyrazine derivatives
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.815534/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.815534/full

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