Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption

Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption

Rationale: Intermittent hypoxia (IH) is one of the main features of sleep-disordered breathing (SDB). Recent findings indicate that hypoxia inducible factor-1 (HIF-1) promotes cardiomyocytes apoptosis during chronic IH, but the mechanisms involved remain to be elucidated. Here, we hypothesize that I...

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Bibliographic Details
Main Authors: Sophie Moulin, Amandine Thomas, Stefan Wagner, Michael Arzt, Hervé Dubouchaud, Frédéric Lamarche, Sophie Bouyon, Guillaume Vial, Diane Godin-Ribuot, Jean-Louis Pépin, Claire Arnaud, Elise Belaidi
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
sleep disordered breathing
intermittent hypoxia
hypoxia inducible factor-1
mitochondria associated-ER membrane
cardiomyocyte death
Online Access:https://www.mdpi.com/2076-3921/11/8/1462

Internet

https://www.mdpi.com/2076-3921/11/8/1462

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