Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway

Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway

Ubiquitin-specific protease 8 (USP8) has been recently reported to be involved in tumorigenesis. Prostate cancer (PCa) is the most diagnosed malignancy among men, but USP8’s role in PCa is not yet investigated comprehensively. Therefore, the PCa cell lines DU145 and PC3 were transfected with USP8 si...

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Bibliographic Details
Main Authors: Md. Tariqul Islam, Fang-Zhi Chen, Han-Chun Chen, Abdul Wahid
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
prostate cancer
USP8
EGFR
PI3K
Docetaxel
NF-kB
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.923270/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.923270/full

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