Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐κB Signaling Pathway

Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐κB Signaling Pathway

Objective To investigate the changes in proinflammatory cytokines and chemokines, namely, C‐C motif ligand (CCL) 2 and CCL7, in postmenopausal osteoporosis (PMOP) and to develop a new drug, bindarit (Bnd), for PMOP in an ovariectomized (OVX) mouse model. Methods Bone marrow macrophages (BMMs) from t...

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Bibliographic Details
Main Authors: Shi‐guo Yuan, Hong‐ling Hu, Xin‐jia Wang, Jin‐cheng Yang, Rong‐ping Zhou, Xiao‐chun Bai, Ping‐lin Lai
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Orthopaedic Surgery
Subjects:
Bindarit
MCP‐1
MCP‐3
Osteoclastogenesis
Osteoporosis
Online Access:https://doi.org/10.1111/os.13252

Internet

https://doi.org/10.1111/os.13252

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