Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammationResearch in context

Background: A positive energy balance promotes white adipose tissue (WAT) expansion which is characterized by activation of a repertoire of events including hypoxia, inflammation and extracellular matrix remodelling. The transmembrane glycoprotein CD248 has been implicated in all these processes in...

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Bibliographic Details
Main Authors: Paul Petrus, Tara L. Fernandez, Michelle M. Kwon, Jenny L. Huang, Victor Lei, Nooshin Seyed Safikhan, Subashini Karunakaran, Daniel J. O'Shannessy, Xiaowei Zheng, Sergiu-Bogdan Catrina, Earl Albone, Jukka Laine, Kirsi Virtanen, Susanne M. Clee, Timothy J. Kieffer, Christophe Noll, André C. Carpentier, James D. Johnson, Mikael Rydén, Edward M. Conway
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419303652