A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant

A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant

Upon systemic administration, adeno-associated virus serotype 9 (AAV9) and the capsid variant PHP.eB show distinct tropism for the central nervous system (CNS), whereas AAV2 and the capsid variant BR1 transduce brain microvascular endothelial cells (BMVECs) with little transcytosis. Here, we show th...

Full description

Bibliographic Details
Main Authors: Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
PHP.B
PHP.eB
BR1
blood-brain barrier
capsid
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000268

Internet

http://www.sciencedirect.com/science/article/pii/S2329050123000268

Similar Items