CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells

CRISPR/Cas9 Mediated Knockout of Cyclooxygenase-2 Gene Inhibits Invasiveness in A2058 Melanoma Cells

The inducible isoenzyme cyclooxygenase-2 (COX-2) is an important hub in cellular signaling, which contributes to tumor progression by modulating and enhancing a pro-inflammatory tumor microenvironment, tumor growth, apoptosis resistance, angiogenesis and metastasis. In order to understand the role o...

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Bibliographic Details
Main Authors: Cathleen Haase-Kohn, Markus Laube, Cornelius K. Donat, Birgit Belter, Jens Pietzsch
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
chemosensitivity
CRISPR/Cas9-knockout
3D-tumor spheroid models
malignant melanoma
radiosensitivity
selective COX-2 inhibitors
Online Access:https://www.mdpi.com/2073-4409/11/4/749

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https://www.mdpi.com/2073-4409/11/4/749

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