Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity

<p>Abstract</p> <p>Background</p> <p>Granulocyte-macrophage colony-stimulating factor (GM-CSF) has shown promising results as a cytokine adjuvant for antiviral vaccines and in various models of tumor gene therapy. To explore whether the targeting of antigens to GM-CSF r...

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Bibliographic Details
Main Authors: Gerlach Nicole, Tippler Bettina, Kuate Seraphin, Tenbusch Matthias, Schimmer Simone, Dittmer Ulf, Überla Klaus
Format: Article
Language:English
Published: BMC 2008-04-01
Series:BMC Immunology
Online Access:http://www.biomedcentral.com/1471-2172/9/13

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http://www.biomedcentral.com/1471-2172/9/13

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