Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation

Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation

Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked adrenoleukodystrophy (X-ALD), a neuroinflammatory disorder, very long-chain fatty acid (VLCFA) accumulation due to impai...

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Bibliographic Details
Main Authors: Ali Tawbeh, Quentin Raas, Mounia Tahri-Joutey, Céline Keime, Romain Kaiser, Doriane Trompier, Boubker Nasser, Emma Bellanger, Marie Dessard, Yannick Hamon, Alexandre Benani, Francesca Di Cara, Tânia Cunha Alves, Johannes Berger, Isabelle Weinhofer, Stéphane Mandard, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Catherine Gondcaille, Stéphane Savary
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
adrenoleukodystrophy
antigen presentation
immune response
inflammation
microglia
peroxisome
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1299314/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1299314/full

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