Increased nonHDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B

Increased nonHDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B

Progressive limb and girdle muscle atrophy leading to loss of ambulation is a hallmark of dysferlinopathies, which include limb-girdle muscular dystrophy type 2B and Miyoshi myopathy. However, animal models fail to fully reproduce the disease severity observed in humans, with dysferlin-null (Dysf−/−...

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Bibliographic Details
Main Authors: Stephanie L. Sellers, Nadia Milad, Zoe White, Chris Pascoe, Rayleigh Chan, Geoffrey W. Payne, Chun Seow, Fabio Rossi, Michael A. Seidman, Pascal Bernatchez
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Journal of Lipid Research
Subjects:
dysferlin
muscular dystrophy
atherosclerosis
apolipoproteins
muscle
HDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520342309

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http://www.sciencedirect.com/science/article/pii/S0022227520342309

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