Establishment of an Olfactory Region-specific Intranasal Delivery Technique in Mice to Target the Central Nervous System

Establishment of an Olfactory Region-specific Intranasal Delivery Technique in Mice to Target the Central Nervous System

We have recently developed a region-specific catheter-based intranasal application method in mice by using CT scan-based 3D cast models of the murine nose (DOI: 10.2376/0005-9366-17,102). This technique is able to specifically deliver drugs to the olfactory region or to the respiratory region only....

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Bibliographic Details
Main Authors: Johannes Flamm, Sunniva Hartung, Stella Gänger, Frank Maigler, Claudia Pitzer, Katharina Schindowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
nose to brain drug delivery
intranasal delivery
delivery method optimisation
animal model
3 R rule
C57BL/6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.789780/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.789780/full

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