The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies
Oligodencrocytes (OLs) are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis (MS), there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells (OPCs) and OLs, resulting in...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=1939;epage=1944;aulast=Dulamea |
| _version_ | 1818963013390041088 |
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| author | Adriana Octaviana Dulamea |
| author_facet | Adriana Octaviana Dulamea |
| author_sort | Adriana Octaviana Dulamea |
| collection | DOAJ |
| description | Oligodencrocytes (OLs) are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis (MS), there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells (OPCs) and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies. |
| first_indexed | 2024-12-20T12:38:28Z |
| format | Article |
| id | doaj.art-911e61433a9d4e959db9426dbbe9b1ac |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-20T12:38:28Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-911e61433a9d4e959db9426dbbe9b1ac2022-12-21T19:40:33ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112121939194410.4103/1673-5374.221146The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategiesAdriana Octaviana DulameaOligodencrocytes (OLs) are the main glial cells of the central nervous system involved in myelination of axons. In multiple sclerosis (MS), there is an imbalance between demyelination and remyelination processes, the last one performed by oligodendrocyte progenitor cells (OPCs) and OLs, resulting into a permanent demyelination, axonal damage and neuronal loss. In MS lesions, astrocytes and microglias play an important part in permeabilization of blood-brain barrier and initiation of OPCs proliferation. Migration and differentiation of OPCs are influenced by various factors and the process is finalized by insufficient acummulation of OLs into the MS lesion. In relation to all these processes, the author will discuss the potential targets for remyelination strategies.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=1939;epage=1944;aulast=Dulameamultiple sclerosis; oligodencrocytes; oligodendrocyte progenitor cells; demyelination; remyelination; semaphorin; basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2; leucin-rich repeat and immunoglobulin-like-domain-containing nogo receptor-interacting protein 1; canonical Notch signaling; endocrine receptors |
| spellingShingle | Adriana Octaviana Dulamea The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies Neural Regeneration Research multiple sclerosis; oligodencrocytes; oligodendrocyte progenitor cells; demyelination; remyelination; semaphorin; basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2; leucin-rich repeat and immunoglobulin-like-domain-containing nogo receptor-interacting protein 1; canonical Notch signaling; endocrine receptors |
| title | The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies |
| title_full | The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies |
| title_fullStr | The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies |
| title_full_unstemmed | The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies |
| title_short | The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies |
| title_sort | contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis perspectives for remyelination therapeutic strategies |
| topic | multiple sclerosis; oligodencrocytes; oligodendrocyte progenitor cells; demyelination; remyelination; semaphorin; basic helix-loop-helix transcription factor oligodendrocyte transcription factor 2; leucin-rich repeat and immunoglobulin-like-domain-containing nogo receptor-interacting protein 1; canonical Notch signaling; endocrine receptors |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=1939;epage=1944;aulast=Dulamea |
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