Lipid flipping in the omega-3 fatty-acid transporter

Abstract Mfsd2a is the transporter for docosahexaenoic acid (DHA), an omega-3 fatty acid, across the blood brain barrier (BBB). Defects in Mfsd2a are linked to ailments from behavioral and motor dysfunctions to microcephaly. Mfsd2a transports long-chain unsaturated fatty-acids, including DHA and α-l...

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Bibliographic Details
Main Authors: Chi Nguyen, Hsiang-Ting Lei, Louis Tung Faat Lai, Marc J. Gallenito, Xuelang Mu, Doreen Matthies, Tamir Gonen
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37702-7