Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys

Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys

Xenotransplantation offers a promising alternative to circumvent the lack of donated human organs available for transplantation. Different attempts to improve the survival of xenografts led to the generation of transgenic pigs expressing various combinations of human protective genes or knocked out...

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Bibliographic Details
Main Authors: Katharina Schmalkuche, Tamina Rother, Sevval Besli, Reinhard Schwinzer, Rainer Blasczyk, Björn Petersen, Constanca Figueiredo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
xenotransplantation
kidney transplantation
ex vivo organ perfusion
T-cell immune response
genetic engineering
programmed cell death-1 ligand 1 (PD-L1)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1279050/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1279050/full

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