Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines

Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines

Abstract Background Cervical cancer (CC) causes more than 311,000 deaths annually worldwide. The integration of human papillomavirus (HPV) is a crucial genetic event that contributes to cervical carcinogenesis. Despite HPV DNA integration is known to disrupt the genomic architecture of both the host...

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Bibliographic Details
Main Authors: Zhijie Wang, Chen Liu, Wanxin Liu, Xinyi Lv, Ting Hu, Fan Yang, Wenhui Yang, Liang He, Xiaoyuan Huang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Genomics
Subjects:
Cervical cancer
HPV integration
HPV16
HPV18
Online Access:https://doi.org/10.1186/s12864-024-10101-y

Internet

https://doi.org/10.1186/s12864-024-10101-y

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