Construction of a Triple-Gene Deletion Mutant of Orf Virus and Evaluation of Its Safety, Immunogenicity and Protective Efficacy

Construction of a Triple-Gene Deletion Mutant of Orf Virus and Evaluation of Its Safety, Immunogenicity and Protective Efficacy

Contagious ecthyma is a zoonotic disease caused by the orf virus (ORFV). Since there is no specific therapeutic drug available, vaccine immunization is the main tool to prevent and control the disease. Previously, we have reported the construction of a double-gene deletion mutant of ORFV (rGS14ΔCBPΔ...

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Bibliographic Details
Main Authors: Zhanning Shen, Bo Liu, Zhen Zhu, Jige Du, Zhiyu Zhou, Chenfan Pan, Yong Chen, Chunsheng Yin, Yufeng Luo, Huanrong Li, Xiaoyun Chen
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Vaccines
Subjects:
ORFV
ORFV 121
recombinant virus
triple-gene deletion
safety
protective efficacy
Online Access:https://www.mdpi.com/2076-393X/11/5/909

Internet

https://www.mdpi.com/2076-393X/11/5/909

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