A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

ST-246 is an oral drug against pathogenic orthopoxvirus infections. An intravenous formulation is required for some critical patients. A ternary complex of ST-246/meglumine/hydroxypropyl-β-cyclodextrin with well-improved solubility was successfully developed in our institute. The aim of this study w...

Full description

Bibliographic Details
Main Authors: Zhiwei Zhang, Shuang Fu, Furun Wang, Chunmiao Yang, Lingchao Wang, Meiyan Yang, Wenpeng Zhang, Wu Zhong, Xiaomei Zhuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
smallpox
ST-246
inclusion complex
PBPK model
dosing regimen
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.836356/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.836356/full

Similar Items