Germline Variants of <i>CYBA</i> and <i>TRPM4</i> Predispose to Familial Colorectal Cancer

Germline Variants of <i>CYBA</i> and <i>TRPM4</i> Predispose to Familial Colorectal Cancer

Familial colorectal cancer (CRC) is only partially explained by known germline predisposing genes. We performed whole-genome sequencing in 15 Polish families of many affected individuals, without mutations in known CRC predisposing genes. We focused on loss-of-function variants and functionally char...

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Bibliographic Details
Main Authors: Lizhen Zhu, Beiping Miao, Dagmara Dymerska, Magdalena Kuswik, Elena Bueno-Martínez, Lara Sanoguera-Miralles, Eladio A. Velasco, Nagarajan Paramasivam, Matthias Schlesner, Abhishek Kumar, Ying Yuan, Jan Lubinski, Obul Reddy Bandapalli, Kari Hemminki, Asta Försti
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
whole-genome sequencing
cancer predisposition
mucin
reactive oxygen species
Online Access:https://www.mdpi.com/2072-6694/14/3/670

Internet

https://www.mdpi.com/2072-6694/14/3/670

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