One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [<sup>99m</sup>Tc]Tc-DB4 and [<sup>111</sup>In]In-SG4 in Mice Treated with Entresto

One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [<sup>99m</sup>Tc]Tc-DB4 and [<sup>111</sup>In]In-SG4 in Mice Treated with Entresto

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...

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Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Aikaterini Kaloudi, Maritina Rouchota, George Loudos, Marion de Jong, Eric P. Krenning, Berthold A. Nock, Theodosia Maina
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
tumor-targeting
peptide radioligand
[<sup>99m</sup>Tc]Tc-DB4
gastrin-releasing peptide receptor
[<sup>111</sup>In]In-SG4
cholecystokinin subtype 2 receptor
Online Access:https://www.mdpi.com/1999-4923/12/12/1145

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https://www.mdpi.com/1999-4923/12/12/1145

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