Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects

Current and Future Therapeutic Approaches for Thymic Stromal Cell Defects

Inborn errors of thymic stromal cell development and function lead to impaired T-cell development resulting in a susceptibility to opportunistic infections and autoimmunity. In their most severe form, congenital athymia, these disorders are life-threatening if left untreated. Athymia is rare and is...

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Bibliographic Details
Main Authors: Alexandra Y. Kreins, Paola Bonfanti, E. Graham Davies
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
thymus transplantation
primary immunodeficiency
DiGeorge syndrome
severe combined immunodeficiency (SCID)
regenerative medicine
PAX1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.655354/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.655354/full

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