KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs

KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs

Abstract Background Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MECP2), is one of the most prevalent neurodevelopmental disorders in girls. However, the underlying mechanism of MECP2 remains largely unknown and currently there is no effective treatment available...

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Bibliographic Details
Main Authors: Ya-Jie Xu, Pei-Pei Liu, Zhong-Ze Yan, Ting-Wei Mi, Ying-Ying Wang, Qian Li, Zhao-Qian Teng, Chang-Mei Liu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Stem Cell Research & Therapy
Subjects:
MECP2
Rett syndrome
Neural differentiation
Cerebral organoids
Online Access:https://doi.org/10.1186/s13287-022-03216-0

Internet

https://doi.org/10.1186/s13287-022-03216-0

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