Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (<i>Phd1</i>) Gene Expressed in Chondrocytes

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (<i>Phd1</i>) Gene Expressed in Chondrocytes

The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin-proteasomal degradation pathway. Of the three PHD...

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Bibliographic Details
Main Authors: Weirong Xing, Destiney Larkin, Sheila Pourteymoor, William Tambunan, Gustavo A. Gomez, Elaine K. Liu, Subburaman Mohan
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Life
Subjects:
prolyl hydroxylase domain-containing protein
PHD protein
<i>Phd1</i> gene
osteoblast
chondrocyte
knockout mice
Online Access:https://www.mdpi.com/2075-1729/13/1/106

Internet

https://www.mdpi.com/2075-1729/13/1/106

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