METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation, and that this promotes glycolysis and tumour gro...

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Bibliographic Details
Main Authors: Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23501-5

Internet

https://doi.org/10.1038/s41467-021-23501-5

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