Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

Abstract Background Microglia play a pivotal role in neuroinflammation, while obesity triggers hypothalamic microglia activation and inflammation. Sirt6 is an important regulator of energy metabolism in many peripheral tissues and hypothalamic anorexic neurons. However, the exact mechanism for micro...

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Bibliographic Details
Main Authors: Xiaoxia Xiao, Huiling Hu, Yadi Zhong, Yingjian Chen, Kaijia Tang, Zhisen Pan, Jiawen Huang, Xiaoying Yang, Qi Wang, Yong Gao
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
Sirt6
Microglial activation
Hypothalamic inflammation
NRF2
Obesity
Online Access:https://doi.org/10.1186/s10020-023-00676-9

Internet

https://doi.org/10.1186/s10020-023-00676-9

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