Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis

Metabolic heterogeneity caused by HLA-DRB1*04:05 and protective effect of inosine on autoimmune hepatitis

Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region. Recently, metabolomics integrated with genomics has identified many genetic loci of biomedical...

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Bibliographic Details
Main Authors: Fan Yang, Leyu Zhou, Yi Shen, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xiaoli Fan, Li Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
autoimmune hepatitis
HLA-DRB1*04:05
metabolomics
inosine
CD4+ T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.982186/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.982186/full

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