Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer’s Disease

Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer’s Disease

All individuals with Down syndrome (DS) eventually develop Alzheimer’s disease (AD) neuropathology, including neurodegeneration, increases in β-amyloid (Aβ) expression, and aggregation and neurofibrillary tangles, between the third and fourth decade of their lives. There is currently no effective tr...

Full description

Bibliographic Details
Main Authors: Verónica Vidal, Alba Puente, Susana García-Cerro, María Teresa García Unzueta, Noemí Rueda, Javier Riancho, Carmen Martínez-Cué
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
Down syndrome
Alzheheimer’s disease
bexarotene
cognition
hypothyroidism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.613211/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.613211/full

Similar Items