Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity

Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity

Summary: Aerobic glycolysis, a metabolic pathway essential for effector T cell survival and proliferation, regulates differentiation of autoimmune T helper (Th) 17 cells, but the mechanism underlying this regulation is largely unknown. Here, we identify a glycolytic intermediate metabolite, phosphoe...

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Bibliographic Details
Main Authors: Tsung-Yen Huang, Masato Hirota, Daiki Sasaki, Rajkumar Singh Kalra, Hsiao-Chiao Chien, Miho Tamai, Shukla Sarkar, Yang Mi, Mio Miyagi, Yu Seto, Hiroki Ishikawa
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002164

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http://www.sciencedirect.com/science/article/pii/S2211124723002164

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