ATR expands embryonic stem cell fate potential in response to replication stress

ATR expands embryonic stem cell fate potential in response to replication stress

Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcr...

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Bibliographic Details
Main Authors: Sina Atashpaz, Sara Samadi Shams, Javier Martin Gonzalez, Endre Sebestyén, Negar Arghavanifard, Andrea Gnocchi, Eliene Albers, Simone Minardi, Giovanni Faga, Paolo Soffientini, Elisa Allievi, Valeria Cancila, Angela Bachi, Óscar Fernández-Capetillo, Claudio Tripodo, Francesco Ferrari, Andrés Joaquin López-Contreras, Vincenzo Costanzo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
ATR
embryonic stem cell
replication stress
Online Access:https://elifesciences.org/articles/54756

Internet

https://elifesciences.org/articles/54756

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