Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1.

Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1.

Monoclonal antibodies (mAbs) directed to extracellular epitopes of human and mouse Platelet Endothelial Cell Adhesion Molecule-1 (CD31 or PECAM-1) stimulate binding of other mAbs to distinct adjacent PECAM-1 epitopes. This effect, dubbed Collaborative Enhancement of Paired Affinity Ligands, or CEPAL...

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Bibliographic Details
Main Authors: Raisa Kiseleva, Colin F Greineder, Carlos H Villa, Elizabeth D Hood, Vladimir V Shuvaev, Jing Sun, Ann-Marie Chacko, Valsamma Abraham, Horace M DeLisser, Vladimir R Muzykantov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5234847?pdf=render

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http://europepmc.org/articles/PMC5234847?pdf=render

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