A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia

Leukocytes that lack HLA allelic expression are frequently detected in patients with acquired aplastic anemia (AA) who respond to immunosuppressive therapy (IST), although the exact mechanisms underlying the HLA loss and HLA allele repertoire likely to acquire loss-of-function mutations are unknown....

Full description

Bibliographic Details
Main Authors: Hiroki Mizumaki, Kazuyoshi Hosomichi, Kohei Hosokawa, Takeshi Yoroidaka, Tatsuya Imi, Yoshitaka Zaimoku, Takamasa Katagiri, Mai Anh Thi Nguyen, Dung Cao Tran, Mahmoud Ibrahim Yousef Elbadry, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hiroyuki Takamatsu, Tatsuhiko Ozawa, Fumihiro Azuma, Hiroyuki Kishi, Yoichi Fujii, Seishi Ogawa, Atsushi Tajima, Shinji Nakao
Format: Article
Language:English
Published: Ferrata Storti Foundation 2020-05-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9763

Internet

https://haematologica.org/article/view/9763

Similar Items