Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Abstract Background Age is the strongest risk factor for the development of Alzheimer’s disease (AD). Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles, emerging evidence demonstrates a critical role of microglia and neuroinflammation in AD pathogenesis. Oleoyl...

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Bibliographic Details
Main Authors: Michele M. Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C. Wang, Jin Wang, Hui Zheng
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Microglia
Oleoylethanolamide
PPARα, TFEB
Online Access:https://doi.org/10.1186/s13024-023-00648-x

Internet

https://doi.org/10.1186/s13024-023-00648-x

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