Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis

Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis

ABSTRACT Zymomonas mobilis is an industrially relevant aerotolerant anaerobic bacterium that can convert up to 96% of consumed glucose to ethanol. This highly catabolic metabolism could be leveraged to produce isoprenoid-based bioproducts via the methylerythritol 4-phosphate (MEP) pathway, but we cu...

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Bibliographic Details
Main Authors: Daven B. Khana, Mehmet Tatli, Julio Rivera Vazquez, Sarathi M. Weraduwage, Noah Stern, Alexander S. Hebert, Edna Angelica Trujillo, David M. Stevenson, Joshua J. Coon, Thomas D. Sharky, Daniel Amador-Noguez
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mSystems
Subjects:
Zymomonas mobilis
MEP pathway
metabolomics
metabolic bottleneck
isoprene
isoprenoid synthesis
Online Access:https://journals.asm.org/doi/10.1128/msystems.00092-23

Internet

https://journals.asm.org/doi/10.1128/msystems.00092-23

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