Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage

Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage

Background: Matrix metalloproteinase (MMP) inhibitors decrease inflammation in normal tissues and suppress cancer progress in normal tissues. Valproic acid (VA) and doxycycline (DX) are MMP inhibitors that have radio-protective effects. Their ability to inhibit MMPs in irradiated tissue is unknown a...

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Bibliographic Details
Main Authors: Ferda Hoşgörler, Didem Keleş, Serpil Tanrıverdi-Akhisaroğlu, Şeniz İnanç, Mustafa Akhisaroğlu, Ülker Cankurt, Zekiye Aydoğdu, Ahmet Deniz Uçar, Oğuz Çetinayak, Gülgün Oktay, Sevil Gönenç Arda
Format: Article
Language:English
Published: Galenos Publishing House 2016-10-01
Series:Balkan Medical Journal
Subjects:
Matrix metalloproteinase
radiation
valproic acid
doxycycline
Online Access:http://balkanmedicaljournal.org/text.php?lang=en&id=22

Internet

http://balkanmedicaljournal.org/text.php?lang=en&id=22

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