Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity

The mammalian imprinted Dlk1-Dio3 locus produces multiple long non-coding RNAs (lncRNAs) from the maternally inherited allele, including Meg3 (i.e., Gtl2) in the mammalian genome. Although this locus has well-characterized functions in stem cell and tumor contexts, its role during neural development...

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Bibliographic Details
Main Authors: Ya-Ping Yen, Wen-Fu Hsieh, Ya-Yin Tsai, Ya-Lin Lu, Ee Shan Liau, Ho-Chiang Hsu, Yen-Chung Chen, Ting-Chun Liu, Mien Chang, Joye Li, Shau-Ping Lin, Jui-Hung Hung, Jun-An Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
motor neuron
long noncoding RNA (lncRNA)
Hox
Ezh2
H3K27me3
Meg3
Online Access:https://elifesciences.org/articles/38080

Internet

https://elifesciences.org/articles/38080

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