Oncolytic Vaccinia Virus Augments T Cell Factor 1-Positive Stem-like CD8<sup>+</sup> T Cells, Which Underlies the Efficacy of Anti-PD-1 Combination Immunotherapy

Oncolytic Vaccinia Virus Augments T Cell Factor 1-Positive Stem-like CD8<sup>+</sup> T Cells, Which Underlies the Efficacy of Anti-PD-1 Combination Immunotherapy

Oncolytic virotherapy has garnered attention as an antigen-agnostic therapeutic cancer vaccine that induces cancer-specific T cell responses without additional antigen loading. As anticancer immune responses are compromised by a lack of antigenicity and chronic immunosuppressive microenvironments, a...

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Bibliographic Details
Main Authors: Yun-Hui Jeon, Namhee Lee, Jiyoon Yoo, Solchan Won, Suk-kyung Shin, Kyu-Hwan Kim, Jun-Gyu Park, Min-Gang Kim, Hang-Rae Kim, Keunhee Oh, Dong-Sup Lee
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
oncolytic vaccinia virus
cancer antigen-specific T cells
stem-like CD8<sup>+</sup> T cells
lymphoid organs
immune checkpoint blockade
Online Access:https://www.mdpi.com/2227-9059/10/4/805

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https://www.mdpi.com/2227-9059/10/4/805

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