Synthetic Optimizations for Gram-Scale Preparation of 1-<i>O</i>-Methyl <span style="font-variant: small-caps">d</span>-<i>Glycero</i>-α-<span style="font-variant: small-caps">d</span>-<i>gluco</i>-heptoside 7-Phosphate from <span style="font-variant: small-caps">d</span>-Glucose

Synthetic Optimizations for Gram-Scale Preparation of 1-<i>O</i>-Methyl <span style="font-variant: small-caps">d</span>-<i>Glycero</i>-α-<span style="font-variant: small-caps">d</span>-<i>gluco</i>-heptoside 7-Phosphate from <span style="font-variant: small-caps">d</span>-Glucose

Heptose phosphates—unique linkers between endotoxic lipid A and <i>O</i>-antigen in the bacterial membrane—are pathogen-associated molecular patterns recognized by the receptors of the innate immune system. Understanding the mechanisms of immune system activation is important for the dev...

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Bibliographic Details
Main Authors: Konstantin V. Potapov, Roman A. Novikov, Pavel N. Solyev, Sergey N. Kochetkov, Alexander A. Makarov, Vladimir A. Mitkevich
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
heptose phosphates
silylation
phosphorylation
bacterial LPS
PAMPs
Online Access:https://www.mdpi.com/1420-3049/27/21/7534

Internet

https://www.mdpi.com/1420-3049/27/21/7534

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