Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B

Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B

Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting. Here, we used recombinant human Galectin-1 (rHsGal-1) as a therapeutic for LGMD2B mouse and human models. Various redox a...

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Bibliographic Details
Main Authors: Mary L. Vallecillo-Zúniga, Peter Daniel Poulson, Jacob S. Luddington, Christian J. Arnold, Matthew Rathgeber, Braden C. Kartchner, Spencer Hayes, Hailie Gill, Jonard C. Valdoz, Jonathan L. Spallino, Seth Garfield, Ethan L. Dodson, Connie M. Arthur, Sean R. Stowell, Pam M. Van Ry
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
Galectin-1
LGMD2B
membrane repair
NF-ĸB
inflammation
cytokines
Online Access:https://www.mdpi.com/2073-4409/10/11/3210

Internet

https://www.mdpi.com/2073-4409/10/11/3210

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