S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

Endogenous and exogenously administered S-nitrosothiols modulate the activities of central and peripheral systems that control breathing. We have unpublished data showing that the deleterious effects of morphine on arterial blood-gas chemistry (i.e., pH, pCO2, pO2, and sO2) and Alveolar-arterial gra...

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Bibliographic Details
Main Authors: Paulina M. Getsy, Santhosh M. Baby, Ryan B. Gruber, Benjamin Gaston, Tristan H. J. Lewis, Alan Grossfield, James M. Seckler, Yee-Hsee Hsieh, James N. Bates, Stephen J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
S-nitrosothiol
fentanyl
frequency of breathing
tidal volume
minute ventilation
noneupneic breathing index
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.892307/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.892307/full

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